Lithium Therapy Improves Neurological Function and Hippocampal Dendritic Arborization in a Spinocerebellar Ataxia Type 1 Mouse Model

BACKGROUND: Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disorder characterized by progressive motor and cognitive dysfunction. Caused by an expanded polyglutamine tract in ataxin 1 (ATXN1), SCA1 pathogenesis involves a multifactorial process that likely begins wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Watase, Kei, Gatchel, Jennifer R, Sun, Yaling, Emamian, Effat, Atkinson, Richard, Richman, Ronald, Mizusawa, Hidehiro, Orr, Harry T, Shaw, Chad, Zoghbi, Huda Y
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1880853/
https://www.ncbi.nlm.nih.gov/pubmed/17535104
http://dx.doi.org/10.1371/journal.pmed.0040182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1880853/
https://www.ncbi.nlm.nih.gov/pubmed/17535104
http://dx.doi.org/10.1371/journal.pmed.0040182

Ejemplares similares