Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol

BACKGROUND: The anticancer drug, 6-mercaptopurine (6MP) is subjected to metabolic clearance through xanthine oxidase (XOD) mediated hydroxylation, producing 6-thiouric acid (6TUA), which is excreted in urine. This reduces the effective amount of drug available for therapeutic efficacy. Co-administra...

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Detalles Bibliográficos
Autores principales: Kalra, Sukirti, Jena, Gopabandhu, Tikoo, Kulbhushan, Mukhopadhyay, Anup Kumar
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885804/
https://www.ncbi.nlm.nih.gov/pubmed/17511860
http://dx.doi.org/10.1186/1471-2091-8-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885804/
https://www.ncbi.nlm.nih.gov/pubmed/17511860
http://dx.doi.org/10.1186/1471-2091-8-8

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