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Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol

BACKGROUND: The anticancer drug, 6-mercaptopurine (6MP) is subjected to metabolic clearance through xanthine oxidase (XOD) mediated hydroxylation, producing 6-thiouric acid (6TUA), which is excreted in urine. This reduces the effective amount of drug available for therapeutic efficacy. Co-administra...

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Detalles Bibliográficos
Autores principales:	Kalra, Sukirti, Jena, Gopabandhu, Tikoo, Kulbhushan, Mukhopadhyay, Anup Kumar
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885804/ https://www.ncbi.nlm.nih.gov/pubmed/17511860 http://dx.doi.org/10.1186/1471-2091-8-8

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