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Generation of Active Protein Phosphatase 2A Is Coupled to Holoenzyme Assembly

Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A holoenzymes assemble, a constitutively active, but nonspecific, catalytic C subunit would constitute a risk to the cell. While it has been assumed...

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Detalles Bibliográficos
Autores principales: Hombauer, Hans, Weismann, David, Mudrak, Ingrid, Stanzel, Claudia, Fellner, Thomas, Lackner, Daniel H, Ogris, Egon
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885835/
https://www.ncbi.nlm.nih.gov/pubmed/17550305
http://dx.doi.org/10.1371/journal.pbio.0050155