The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis

Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with Eμ-directed expression of the XBP-1 spliced isoform (XBP-1s), a factor governing un...

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Detalles Bibliográficos
Autores principales: Carrasco, Daniel R., Sukhdeo, Kumar, Protopopova, Marina, Sinha, Raktim, Enos, Miriam, Carrasco, Daniel E., Zheng, Mei, Mani, Mala, Henderson, Joel, Pinkus, Geraldine S., Munshi, Nikhil, Horner, James, Ivanova, Elena V., Protopopov, Alexei, Anderson, Kenneth C., Tonon, Giovanni, DePinho, Ronald A.
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885943/
https://www.ncbi.nlm.nih.gov/pubmed/17418411
http://dx.doi.org/10.1016/j.ccr.2007.02.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885943/
https://www.ncbi.nlm.nih.gov/pubmed/17418411
http://dx.doi.org/10.1016/j.ccr.2007.02.015

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