Cargando…

The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis

Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with Eμ-directed expression of the XBP-1 spliced isoform (XBP-1s), a factor governing un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carrasco, Daniel R., Sukhdeo, Kumar, Protopopova, Marina, Sinha, Raktim, Enos, Miriam, Carrasco, Daniel E., Zheng, Mei, Mani, Mala, Henderson, Joel, Pinkus, Geraldine S., Munshi, Nikhil, Horner, James, Ivanova, Elena V., Protopopov, Alexei, Anderson, Kenneth C., Tonon, Giovanni, DePinho, Ronald A.
Formato:	Texto
Lenguaje:	English
Publicado:	Cell Press 2007
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885943/ https://www.ncbi.nlm.nih.gov/pubmed/17418411 http://dx.doi.org/10.1016/j.ccr.2007.02.015

Ejemplares similares

Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: A potential therapeutic application in multiple myeloma
por: Bae, Jooeun, et al.
Publicado: (2011)

A Multiepitope of XBP1, CD138 and CS1 Peptides Induces Myeloma-Specific Cytotoxic T lymphocytes in T cells of Smoldering Myeloma Patients
por: Bae, Jooeun, et al.
Publicado: (2014)

Telomere dysfunction suppresses multiple endocrine neoplasia in mice
por: Lee, Ji-Hyeon, et al.
Publicado: (2014)

PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription
por: Lew, Qiao Jing, et al.
Publicado: (2011)

Telomerase reactivation reverses tissue degeneration in aged telomerase deficient mice
por: Jaskelioff, Mariela, et al.
Publicado: (2010)

Role of Telomere Dysfunction in Cardiac Failure in Duchenne Muscular Dystrophy
por: Mourkioti, Foteini, et al.
Publicado: (2013)

XBP-1 image overhaul
por: Van Epps, Heather L.
Publicado: (2005)

Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s
por: Zang, Meirong, et al.
Publicado: (2020)

Deep Response in Multiple Myeloma: A Critical Review
por: Fulciniti, Mariateresa, et al.
Publicado: (2015)

Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential
por: Shammas, Masood A, et al.
Publicado: (2005)

Multiple Myeloma-Derived Extracellular Vesicles Induce Osteoclastogenesis through the Activation of the XBP1/IRE1α Axis
por: Raimondi, Lavinia, et al.
Publicado: (2020)

The Role of XBP1 in bone metabolism
por: Lv, Wenhao, et al.
Publicado: (2023)

pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
por: Yoshida, Hiderou, et al.
Publicado: (2006)

Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3(+)CD8(+) T cells against Various Solid Tumors
por: Bae, Jooeun, et al.
Publicado: (2015)

The transcription factor XBP-1 in neurodegenerative diseases
por: Checler, Frédéric, et al.
Publicado: (2013)

Protein Arginine Methyltransferase 5 (PRMT5) has prognostic relevance and is a druggable target in Multiple Myeloma
por: Gullà, Annamaria, et al.
Publicado: (2017)

XBP-1 Remodels Lipid Metabolism to Extend Longevity
por: Imanikia, Soudabeh, et al.
Publicado: (2019)

Roles of XBP1s in Transcriptional Regulation of Target Genes
por: Park, Sung-Min, et al.
Publicado: (2021)

UPR Responsive Genes Manf and Xbp1 in Stroke
por: Lõhelaid, Helike, et al.
Publicado: (2022)

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing
por: Ri, M, et al.
Publicado: (2012)

Telomere Dysfunction as an Initiator of Inflammation: Clues to an Age-Old Mystery
por: Chakravarti, Deepavali, et al.
Publicado: (2021)

The Y of cancer sex differences
por: Li, Jiexi, et al.
Publicado: (2023)

Bortezomib in the management of multiple myeloma
por: Laubach, Jacob P, et al.
Publicado: (2009)

Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78
por: Borjan, Bojana, et al.
Publicado: (2020)

The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival
por: Ohguchi, Hiroto, et al.
Publicado: (2016)

The Treatment of Multiple Myeloma Patients Not Eligible for Asct
por: Richardson, Paul, et al.
Publicado: (2010)

Lack of XBP-1 Impedes Murine Cytomegalovirus Gene Expression
por: Drori, Adi, et al.
Publicado: (2014)

The transcription factor XBP1 is selectively required for eosinophil differentiation
por: Bettigole, Sarah E., et al.
Publicado: (2015)

Effect of Denervation on XBP1 in Skeletal Muscle and the Neuromuscular Junction
por: Walter, Lisa A., et al.
Publicado: (2021)

Molecular Mechanism Underlying Role of the XBP1s in Cardiovascular Diseases
por: Liu, Shu, et al.
Publicado: (2022)

Lenalidomide in multiple myeloma: an evidence-based review of its role in therapy
por: Richardson, Paul, et al.
Publicado: (2010)

RNA-Seq analysis in MeV
por: Howe, Eleanor A., et al.
Publicado: (2011)

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response
por: Chalmers, Fiona, et al.
Publicado: (2017)

The Role of lncRNAs in the Pathobiology and Clinical Behavior of Multiple Myeloma
por: Carrasco-León, Arantxa, et al.
Publicado: (2021)

Monoallelic deletion of BCMA is a frequent feature in multiple myeloma
por: Samur, Mehmet Kemal, et al.
Publicado: (2023)

The transcription factor XBP-1 is essential for the development and survival of dendritic cells
por: Iwakoshi, Neal N., et al.
Publicado: (2007)

Differential Activation of the ER Stress Factor XBP1 by Oligomeric Assemblies
por: Castillo-Carranza, Diana L., et al.
Publicado: (2012)

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity
por: Deng, Yingfeng, et al.
Publicado: (2018)

Structural and mutational analysis of the ribosome-arresting human XBP1u
por: Shanmuganathan, Vivekanandan, et al.
Publicado: (2019)

Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells
por: Shi, Weimei, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6aiepng77rpl94mm8ntu5l5per