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Rearrangement and Expression of Immunoglobulin Light Chain Genes Can Precede Heavy Chain Expression during Normal B Cell Development in Mice
In mouse mutants incapable of expressing μ chains, V(κ)J(κ )joints are detected in the CD43(+) B cell progenitors. In agreement with these earlier results, we show by a molecular single cell analysis that 4–7% of CD43(+) B cell progenitors in wild-type mice rearrange immunoglobulin (Ig)κ genes befor...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1999
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887695/ https://www.ncbi.nlm.nih.gov/pubmed/9874565 |