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Rearrangement and Expression of Immunoglobulin Light Chain Genes Can Precede Heavy Chain Expression during Normal B Cell Development in Mice

In mouse mutants incapable of expressing μ chains, V(κ)J(κ )joints are detected in the CD43(+) B cell progenitors. In agreement with these earlier results, we show by a molecular single cell analysis that 4–7% of CD43(+) B cell progenitors in wild-type mice rearrange immunoglobulin (Ig)κ genes befor...

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Detalles Bibliográficos
Autores principales:	Novobrantseva, Tatiana I., Martin, Verena M., Pelanda, Roberta, Müller, Werner, Rajewsky, Klaus, Ehlich, Andreas
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1999
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887695/ https://www.ncbi.nlm.nih.gov/pubmed/9874565

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