Charged Residues between the Selectivity Filter and S6 Segments Contribute to the Permeation Phenotype of the Sodium Channel

The deep regions of the Na(+) channel pore around the selectivity filter have been studied extensively; however, little is known about the adjacent linkers between the P loops and S6. The presence of conserved charged residues, including five in a row in domain III (D-III), hints that these linkers...

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Detalles Bibliográficos
Autores principales: Li, Ronald A., Vélez, Patricio, Chiamvimonvat, Nipavan, Tomaselli, Gordon F., Marbán, Eduardo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887778/
https://www.ncbi.nlm.nih.gov/pubmed/10613920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887778/
https://www.ncbi.nlm.nih.gov/pubmed/10613920

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