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Binding induced conformational changes of proteins correlate with their intrinsic fluctuations: a case study of antibodies
BACKGROUND: How antibodies recognize and bind to antigens can not be totally explained by rigid shape and electrostatic complimentarity models. Alternatively, pre-existing equilibrium hypothesis states that the native state of an antibody is not defined by a single rigid conformation but instead wit...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888692/ https://www.ncbi.nlm.nih.gov/pubmed/17509130 http://dx.doi.org/10.1186/1472-6807-7-31 |