Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5′ untranslated region

BACE1 is the protease responsible for the production of amyloid-β peptides that accumulate in the brain of Alzheimer's disease (AD) patients. BACE1 expression is regulated at the transcriptional, as well as post-transcriptional level. Very high BACE1 mRNA levels have been observed in pancreas,...

Descripción completa

Detalles Bibliográficos
Autores principales: Mihailovich, Marija, Thermann, Rolf, Grohovaz, Fabio, Hentze, Matthias W., Zacchetti, Daniele
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888809/
https://www.ncbi.nlm.nih.gov/pubmed/17439957
http://dx.doi.org/10.1093/nar/gkm191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888809/
https://www.ncbi.nlm.nih.gov/pubmed/17439957
http://dx.doi.org/10.1093/nar/gkm191

Ejemplares similares