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Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5′ untranslated region
BACE1 is the protease responsible for the production of amyloid-β peptides that accumulate in the brain of Alzheimer's disease (AD) patients. BACE1 expression is regulated at the transcriptional, as well as post-transcriptional level. Very high BACE1 mRNA levels have been observed in pancreas,...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888809/ https://www.ncbi.nlm.nih.gov/pubmed/17439957 http://dx.doi.org/10.1093/nar/gkm191 |