Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity

FEN-1 and XPG are members of the FEN-1 family of structure-specific nucleases, which share a conserved active site. FEN-1 plays a central role in DNA replication, whereas XPG is involved in nucleotide excision repair (NER). Both FEN-1 and XPG are active on flap structures, but only XPG cleaves bubbl...

Descripción completa

Detalles Bibliográficos
Autores principales: Hohl, Marcel, Dunand-Sauthier, Isabelle, Staresincic, Lidija, Jaquier-Gubler, Pascale, Thorel, Fabrizio, Modesti, Mauro, Clarkson, Stuart G., Schärer, Orlando D.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888826/
https://www.ncbi.nlm.nih.gov/pubmed/17452369
http://dx.doi.org/10.1093/nar/gkm092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888826/
https://www.ncbi.nlm.nih.gov/pubmed/17452369
http://dx.doi.org/10.1093/nar/gkm092

Ejemplares similares