Interpretation of knockout experiments: the congenic footprint

In gene targeting experiments, the importance of genetic background is now widely appreciated, and knockout alleles are routinely backcrossed onto a standard inbred background. This produces a congenic strain with a substantial segment of embryonic stem (ES)-cell-derived chromosome still flanking th...

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Detalles Bibliográficos
Autores principales: Schalkwyk, L C, Fernandes, C, Nash, M W, Kurrikoff, K, Vasar, E, Kõks, S
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2007
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890814/
https://www.ncbi.nlm.nih.gov/pubmed/17331107
http://dx.doi.org/10.1111/j.1601-183X.2007.00304.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890814/
https://www.ncbi.nlm.nih.gov/pubmed/17331107
http://dx.doi.org/10.1111/j.1601-183X.2007.00304.x

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