Triterpenoids Display Single Agent Anti-tumor Activity in a Transgenic Mouse Model of Chronic Lymphocytic Leukemia and Small B Cell Lymphoma

BACKGROUND: The synthetic triterpenoid 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic Acid (CDDO) and derivatives display anti-tumor activity against a variety of cultured tumor cell lines and in mouse xenografts. In this report, we have studied the effects of CDDO and its imidazolide derivative (CDDO-Im)...

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Detalles Bibliográficos
Autores principales: Kress, Christina L., Konopleva, Marina, Martínez-García, Vanesa, Krajewska, Maryla, Lefebvre, Sophie, Hyer, Marc L., McQueen, Teresa, Andreeff, Michael, Reed, John C., Zapata, Juan M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891436/
https://www.ncbi.nlm.nih.gov/pubmed/17593960
http://dx.doi.org/10.1371/journal.pone.0000559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891436/
https://www.ncbi.nlm.nih.gov/pubmed/17593960
http://dx.doi.org/10.1371/journal.pone.0000559

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