O(6)-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies

BACKGROUND: A novel alkylating agent, temozolomide, has proven efficacious in the treatment of malignant gliomas. However, expression of O(6)-methylguanine-DNA methyltransferase (MGMT) renders glioma cells resistant to the treatment, indicating that identification of mechanisms underlying the gene r...

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Detalles Bibliográficos
Autores principales: Sasai, Ken, Akagi, Tsuyoshi, Aoyanagi, Eiko, Tabu, Kouichi, Kaneko, Sadao, Tanaka, Shinya
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892783/
https://www.ncbi.nlm.nih.gov/pubmed/17547775
http://dx.doi.org/10.1186/1476-4598-6-36

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892783/
https://www.ncbi.nlm.nih.gov/pubmed/17547775
http://dx.doi.org/10.1186/1476-4598-6-36

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