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O(6)-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies

BACKGROUND: A novel alkylating agent, temozolomide, has proven efficacious in the treatment of malignant gliomas. However, expression of O(6)-methylguanine-DNA methyltransferase (MGMT) renders glioma cells resistant to the treatment, indicating that identification of mechanisms underlying the gene r...

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Detalles Bibliográficos
Autores principales:	Sasai, Ken, Akagi, Tsuyoshi, Aoyanagi, Eiko, Tabu, Kouichi, Kaneko, Sadao, Tanaka, Shinya
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892783/ https://www.ncbi.nlm.nih.gov/pubmed/17547775 http://dx.doi.org/10.1186/1476-4598-6-36

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