HTLV-1 Tax mutants that do not induce G(1 )arrest are disabled in activating the anaphase promoting complex

HTLV-1 Tax is a potent activator of viral transcription and NF-κB. Recent data indicate that Tax activates the anaphase promoting complex/cyclosome (APC/C) ahead of schedule, causing premature degradation of cyclin A, cyclin B1, securin, and Skp2. Premature loss of these mitotic regulators is accomp...

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Detalles Bibliográficos
Autores principales: Merling, Randall, Chen, Chunhua, Hong, Sohee, Zhang, Ling, Liu, Meihong, Kuo, Yu-Liang, Giam, Chou-Zen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894815/
https://www.ncbi.nlm.nih.gov/pubmed/17535428
http://dx.doi.org/10.1186/1742-4690-4-35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894815/
https://www.ncbi.nlm.nih.gov/pubmed/17535428
http://dx.doi.org/10.1186/1742-4690-4-35

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