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HTLV-1 Tax mutants that do not induce G(1 )arrest are disabled in activating the anaphase promoting complex
HTLV-1 Tax is a potent activator of viral transcription and NF-κB. Recent data indicate that Tax activates the anaphase promoting complex/cyclosome (APC/C) ahead of schedule, causing premature degradation of cyclin A, cyclin B1, securin, and Skp2. Premature loss of these mitotic regulators is accomp...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894815/ https://www.ncbi.nlm.nih.gov/pubmed/17535428 http://dx.doi.org/10.1186/1742-4690-4-35 |