Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA

Oxazole-containing macrocycles represent a promising class of anticancer agents that target G-quadruplex DNA. We report the results of spectroscopic studies aimed at defining the mode, energetics and specificity with which a hexaoxazole-containing macrocycle (HXDV) binds to the intramolecular quadru...

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Detalles Bibliográficos
Autores principales: Barbieri, Christopher M., Srinivasan, Annankoil R., Rzuczek, Suzanne G., Rice, Joseph E., LaVoie, Edmond J., Pilch, Daniel S.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904271/
https://www.ncbi.nlm.nih.gov/pubmed/17452355
http://dx.doi.org/10.1093/nar/gkm188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904271/
https://www.ncbi.nlm.nih.gov/pubmed/17452355
http://dx.doi.org/10.1093/nar/gkm188

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