Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes

The mechanism of mitochondrial DNA replication is a subject of intense debate. One model proposes a strand-asynchronous replication in which both strands of the circular genome are replicated semi-independently while the other model proposes both a bidirectional coupled leading- and lagging-strand s...

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Detalles Bibliográficos
Autores principales: Wanrooij, Sjoerd, Goffart, Steffi, Pohjoismäki, Jaakko L.O., Yasukawa, Takehiro, Spelbrink, Johannes N.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904276/
https://www.ncbi.nlm.nih.gov/pubmed/17452351
http://dx.doi.org/10.1093/nar/gkm215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904276/
https://www.ncbi.nlm.nih.gov/pubmed/17452351
http://dx.doi.org/10.1093/nar/gkm215

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