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Position and distance specificity are important determinants of cis-regulatory motifs in addition to evolutionary conservation
Computational discovery of cis-regulatory elements remains challenging. To cope with the high false positives, evolutionary conservation is routinely used. However, conservation is only one of the attributes of cis-regulatory elements and is neither necessary nor sufficient. Here, we assess two addi...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904283/ https://www.ncbi.nlm.nih.gov/pubmed/17452354 http://dx.doi.org/10.1093/nar/gkm201 |