The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage

Meganucleases are sequence-specific endonucleases with large cleavage sites that can be used to induce efficient homologous gene targeting in cultured cells and plants. These enzymes open novel perspectives for genome engineering in a wide range of fields, including gene therapy. A new crystal struc...

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Detalles Bibliográficos
Autores principales: Prieto, Jesús, Redondo, Pilar, Padró, Daniel, Arnould, Sylvain, Epinat, Jean-Charles, Pâques, Frédéric, Blanco, Francisco J., Montoya, Guillermo
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904291/
https://www.ncbi.nlm.nih.gov/pubmed/17452357
http://dx.doi.org/10.1093/nar/gkm183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904291/
https://www.ncbi.nlm.nih.gov/pubmed/17452357
http://dx.doi.org/10.1093/nar/gkm183

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