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The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage
Meganucleases are sequence-specific endonucleases with large cleavage sites that can be used to induce efficient homologous gene targeting in cultured cells and plants. These enzymes open novel perspectives for genome engineering in a wide range of fields, including gene therapy. A new crystal struc...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904291/ https://www.ncbi.nlm.nih.gov/pubmed/17452357 http://dx.doi.org/10.1093/nar/gkm183 |