Rational design of an estrogen receptor mutant with altered DNA-binding specificity

Although artificial C2-H2 zinc fingers can be designed to recognize specific DNA sequences, it remains unclear to which extent nuclear receptor C4 zinc fingers can be tailored to bind novel DNA elements. Steroid receptors bind as dimers to palindromic response elements differing in the two central b...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Denis, Bail, Martine, Pesant, Genevieve, Dupont, Virginie N., Rouault, Étienne, Deschênes, Julie, Rocha, Walter, Melançon, Geneviève, Steinberg, Sergey V., Mader, Sylvie
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904296/
https://www.ncbi.nlm.nih.gov/pubmed/17478511
http://dx.doi.org/10.1093/nar/gkm241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904296/
https://www.ncbi.nlm.nih.gov/pubmed/17478511
http://dx.doi.org/10.1093/nar/gkm241

Ejemplares similares