Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis

BACKGROUND: Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease. METHODS: Circulating leukocytes were phenotyped in patients receiving alefacept for moderate to severe psoriasis. RESULTS: In all patients,...

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Autores principales: Chamian, Francesca, Lin, Shao-Lee, Lee, Edmund, Kikuchi, Toyoko, Gilleaudeau, Patricia, Sullivan-Whalen, Mary, Cardinale, Irma, Khatcherian, Artemis, Novitskaya, Inna, Wittkowski, Knut M, Krueger, James G, Lowes, Michelle A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906741/
https://www.ncbi.nlm.nih.gov/pubmed/17555598
http://dx.doi.org/10.1186/1479-5876-5-27
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author Chamian, Francesca
Lin, Shao-Lee
Lee, Edmund
Kikuchi, Toyoko
Gilleaudeau, Patricia
Sullivan-Whalen, Mary
Cardinale, Irma
Khatcherian, Artemis
Novitskaya, Inna
Wittkowski, Knut M
Krueger, James G
Lowes, Michelle A
author_facet Chamian, Francesca
Lin, Shao-Lee
Lee, Edmund
Kikuchi, Toyoko
Gilleaudeau, Patricia
Sullivan-Whalen, Mary
Cardinale, Irma
Khatcherian, Artemis
Novitskaya, Inna
Wittkowski, Knut M
Krueger, James G
Lowes, Michelle A
author_sort Chamian, Francesca
collection PubMed
description BACKGROUND: Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease. METHODS: Circulating leukocytes were phenotyped in patients receiving alefacept for moderate to severe psoriasis. RESULTS: In all patients, this treatment caused a preferential decrease in effector memory T cells (CCR7(- )CD45RA(-)) (mean 63% reduction) for both CD4(+ )and CD8(+ )Tem, while central memory T cells (Tcm) (CCR7(+)CD45RA(-)) were less affected, and naïve T cells (CCR7(+)CD45RA(+)) were relatively spared. Circulating CD8(+ )effector T cells and Type 1 T cells (IFN-γ-producing) were also significantly reduced. CONCLUSION: Alefacept causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.
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spelling pubmed-19067412007-07-04 Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis Chamian, Francesca Lin, Shao-Lee Lee, Edmund Kikuchi, Toyoko Gilleaudeau, Patricia Sullivan-Whalen, Mary Cardinale, Irma Khatcherian, Artemis Novitskaya, Inna Wittkowski, Knut M Krueger, James G Lowes, Michelle A J Transl Med Research BACKGROUND: Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease. METHODS: Circulating leukocytes were phenotyped in patients receiving alefacept for moderate to severe psoriasis. RESULTS: In all patients, this treatment caused a preferential decrease in effector memory T cells (CCR7(- )CD45RA(-)) (mean 63% reduction) for both CD4(+ )and CD8(+ )Tem, while central memory T cells (Tcm) (CCR7(+)CD45RA(-)) were less affected, and naïve T cells (CCR7(+)CD45RA(+)) were relatively spared. Circulating CD8(+ )effector T cells and Type 1 T cells (IFN-γ-producing) were also significantly reduced. CONCLUSION: Alefacept causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis. BioMed Central 2007-06-07 /pmc/articles/PMC1906741/ /pubmed/17555598 http://dx.doi.org/10.1186/1479-5876-5-27 Text en Copyright © 2007 Chamian et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Chamian, Francesca
Lin, Shao-Lee
Lee, Edmund
Kikuchi, Toyoko
Gilleaudeau, Patricia
Sullivan-Whalen, Mary
Cardinale, Irma
Khatcherian, Artemis
Novitskaya, Inna
Wittkowski, Knut M
Krueger, James G
Lowes, Michelle A
Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
title Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
title_full Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
title_fullStr Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
title_full_unstemmed Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
title_short Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis
title_sort alefacept (anti-cd2) causes a selective reduction in circulating effector memory t cells (tem) and relative preservation of central memory t cells (tcm) in psoriasis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906741/
https://www.ncbi.nlm.nih.gov/pubmed/17555598
http://dx.doi.org/10.1186/1479-5876-5-27
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