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The Role of Rab3a in Secretory Vesicle Docking Requires Association/Dissociation of Guanidine Phosphates and Munc18-1

Rab3a is a small GTPase that binds selectively to secretory vesicles and switches between active, GTP-bound and inactive, GDP-bound conformations. In yeast, Rab and SM-genes interact genetically to promote vesicle targeting/fusion. We tested different Rab3a conformations and genetic interactions wit...

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Detalles Bibliográficos
Autores principales: van Weering, Jan R.T., Toonen, Ruud F., Verhage, Matthijs
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1910611/
https://www.ncbi.nlm.nih.gov/pubmed/17637832
http://dx.doi.org/10.1371/journal.pone.0000616