Cloning and characterization of an adenoviral vector for highly efficient and doxycycline – suppressible expression of bioactive human single – chain interleukin 12 in colon cancer

BACKGROUND: Interleukin-12 (IL-12) is well characterized to induce cellular antitumoral immunity by activation of NK-cells and T-lymphocytes. However, systemic administration of recombinant human IL-12 resulted in severe toxicity without perceptible therapeutic benefit. Even though intratumoral expr...

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Detalles Bibliográficos
Autores principales: Wulff, Holger, Krieger, Thorsten, Krüger, Karen, Stahmer, Ingrid, Thaiss, Friedrich, Schäfer, Hansjörg, Block, Andreas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913502/
https://www.ncbi.nlm.nih.gov/pubmed/17594499
http://dx.doi.org/10.1186/1472-6750-7-35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913502/
https://www.ncbi.nlm.nih.gov/pubmed/17594499
http://dx.doi.org/10.1186/1472-6750-7-35

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