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Presence of thiamine pyrophosphate in mammalian peroxisomes

BACKGROUND: Thiamine pyrophosphate (TPP) is a cofactor for 2-hydroxyacyl-CoA lyase 1 (HACL1), a peroxisomal enzyme essential for the α-oxidation of phytanic acid and 2-hydroxy straight chain fatty acids. So far, HACL1 is the only known peroxisomal TPP-dependent enzyme in mammals. Little is known abo...

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Detalles Bibliográficos
Autores principales: Fraccascia, Patrizia, Sniekers, Mieke, Casteels, Minne, Van Veldhoven, Paul P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913525/
https://www.ncbi.nlm.nih.gov/pubmed/17596263
http://dx.doi.org/10.1186/1471-2091-8-10