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Transcriptional response of pancreatic beta cells to metabolic stimulation: large scale identification of immediate-early and secondary response genes

BACKGROUND: Physiological long term adaptation of pancreatic beta cells is driven by stimuli such as glucose and incretin hormones acting via cAMP (e.g. GLP-1) and involves regulated gene expression. Several rapidly inducible immediate-early genes (IEGs) have been identified in beta cells. Many of t...

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Detalles Bibliográficos
Autores principales: Glauser, Dominique A, Brun, Thierry, Gauthier, Benoit R, Schlegel, Werner
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914353/
https://www.ncbi.nlm.nih.gov/pubmed/17587450
http://dx.doi.org/10.1186/1471-2199-8-54