A First-Principles Model of Early Evolution: Emergence of Gene Families, Species, and Preferred Protein Folds

In this work we develop a microscopic physical model of early evolution where phenotype—organism life expectancy—is directly related to genotype—the stability of its proteins in their native conformations—which can be determined exactly in the model. Simulating the model on a computer, we consistent...

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Detalles Bibliográficos
Autores principales: Zeldovich, Konstantin B, Chen, Peiqiu, Shakhnovich, Boris E, Shakhnovich, Eugene I
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914367/
https://www.ncbi.nlm.nih.gov/pubmed/17630830
http://dx.doi.org/10.1371/journal.pcbi.0030139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914367/
https://www.ncbi.nlm.nih.gov/pubmed/17630830
http://dx.doi.org/10.1371/journal.pcbi.0030139

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