Polyglutamine Expansion Mutation Yields a Pathological Epitope Linked to Nucleation of Protein Aggregate: Determinant of Huntington's Disease Onset

Polyglutamine (polyQ) expansion mutation causes conformational, neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. These diseases are characterized by the aggregation of misfolded proteins, such as amyloid fibrils, which are toxic to cells. Amyloid fibrils are formed...

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Detalles Bibliográficos
Autores principales: Sugaya, Keizo, Matsubara, Shiro, Kagamihara, Yasuhiro, Kawata, Akihiro, Hayashi, Hideaki
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914377/
https://www.ncbi.nlm.nih.gov/pubmed/17653262
http://dx.doi.org/10.1371/journal.pone.0000635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914377/
https://www.ncbi.nlm.nih.gov/pubmed/17653262
http://dx.doi.org/10.1371/journal.pone.0000635

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