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The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat

RATIONALE: The selective type IV phosphodiesterase inhibitor, rolipram, has been shown to improve long-term memory and can reverse the cholinergic deficit caused by scopolamine. However, the underlying mechanisms of action of rolipram remain obscure. OBJECTIVES: The present study investigates the ef...

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Detalles Bibliográficos
Autores principales:	Rutten, K., Lieben, C., Smits, L., Blokland, A.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2007
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1915617/ https://www.ncbi.nlm.nih.gov/pubmed/17265077 http://dx.doi.org/10.1007/s00213-006-0697-4

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