Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study

Cytochrome P450 2D6 (CYP2D6) is one of the most important cytochromes P450 in humans. Resonance Raman data from the T309V mutant of CYP2D6 show that the substitution of the conserved I-helix threonine situated in the enzyme’s active site perturbs the heme spin equilibrium in favor of the six-coordin...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonifacio, Alois, Groenhof, André R., Keizers, Peter H. J., de Graaf, Chris, Commandeur, Jan N. M., Vermeulen, Nico P. E., Ehlers, Andreas W., Lammertsma, Koop, Gooijer, Cees, van der Zwan, Gert
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2007
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1915625/
https://www.ncbi.nlm.nih.gov/pubmed/17318599
http://dx.doi.org/10.1007/s00775-007-0210-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1915625/
https://www.ncbi.nlm.nih.gov/pubmed/17318599
http://dx.doi.org/10.1007/s00775-007-0210-5

Ejemplares similares