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HIF-2α downregulation in the absence of functional VHL is not sufficient for renal cell differentiation
BACKGROUND: Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hypoxia-inducible factor alpha (HIF-α) subunits for ubiquitination and subsequent...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919349/ https://www.ncbi.nlm.nih.gov/pubmed/17598890 http://dx.doi.org/10.1186/1475-2867-7-13 |