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HIF-2α downregulation in the absence of functional VHL is not sufficient for renal cell differentiation

BACKGROUND: Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hypoxia-inducible factor alpha (HIF-α) subunits for ubiquitination and subsequent...

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Detalles Bibliográficos
Autores principales:	Hughes, Michael D, Kapllani, Erilda, Alexander, Ashlynn E, Burk, Robert D, Schoenfeld, Alan R
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919349/ https://www.ncbi.nlm.nih.gov/pubmed/17598890 http://dx.doi.org/10.1186/1475-2867-7-13

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