Cargando…
Uracil–DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms
DNA glycosylases UNG and SMUG1 excise uracil from DNA and belong to the same protein superfamily. Vertebrates contain both SMUG1 and UNG, but their distinct roles in base excision repair (BER) of deaminated cytosine (U:G) are still not fully defined. Here we have examined the ability of human SMUG1...
Autores principales: | Pettersen, Henrik Sahlin, Sundheim, Ottar, Gilljam, Karin Margaretha, Slupphaug, Geir, Krokan, Hans Einar, Kavli, Bodil |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919486/ https://www.ncbi.nlm.nih.gov/pubmed/17537817 http://dx.doi.org/10.1093/nar/gkm372 |
Ejemplares similares
-
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation
por: Pettersen, Henrik Sahlin, et al.
Publicado: (2011) -
Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil
por: Sarno, Antonio, et al.
Publicado: (2019) -
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil
por: Kavli, Bodil, et al.
Publicado: (2005) -
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung(−/−)Msh2(−/−) mice
por: Kemmerich, Kristin, et al.
Publicado: (2012) -
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA
por: Hagen, Lars, et al.
Publicado: (2008)