Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent

Mitoxantrone is an anti-cancer agent used in the treatment of breast and prostate cancers. It is classified as a topoisomerase II poison, however can also be activated by formaldehyde to generate drug–DNA adducts. Despite identification of this novel form of mitoxantrone–DNA interaction, excessively...

Descripción completa

Detalles Bibliográficos
Autores principales: Evison, Ben J., Mansour, Oula C., Menta, Ernesto, Phillips, Don R., Cutts, Suzanne M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920253/
https://www.ncbi.nlm.nih.gov/pubmed/17483512
http://dx.doi.org/10.1093/nar/gkm285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920253/
https://www.ncbi.nlm.nih.gov/pubmed/17483512
http://dx.doi.org/10.1093/nar/gkm285

Ejemplares similares