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DNA topoisomerase II selects DNA cleavage sites based on reactivity rather than binding affinity
DNA topoisomerase II modulates DNA topology by relieving supercoil stress and by unknotting or decatenating entangled DNA. During its reaction cycle, the enzyme creates a transient double-strand break in one DNA segment, the G-DNA. This break serves as a gate through which another DNA segment is tra...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920260/ https://www.ncbi.nlm.nih.gov/pubmed/17517767 http://dx.doi.org/10.1093/nar/gkm335 |