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Bayesian estimates of linkage disequilibrium
BACKGROUND: The maximum likelihood estimator of D' – a standard measure of linkage disequilibrium – is biased toward disequilibrium, and the bias is particularly evident in small samples and rare haplotypes. RESULTS: This paper proposes a Bayesian estimation of D' to address this problem....
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924864/ https://www.ncbi.nlm.nih.gov/pubmed/17592642 http://dx.doi.org/10.1186/1471-2156-8-36 |