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Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Using highly purified hematopoietic stem cells from mice aged 2 to 21 mo, we demonstrate a deficit in function yet an increase in stem cell number with advancing age. Expression analys...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925137/ https://www.ncbi.nlm.nih.gov/pubmed/17676974 http://dx.doi.org/10.1371/journal.pbio.0050201 |