Towards the uniform distribution of null P values on Affymetrix microarrays

Methods to control false-positive rates require that P values of genes that are not differentially expressed follow a uniform distribution. Commonly used microarray statistics can generate P values that do not meet this assumption. We show that poorly characterized variance, imperfect normalization,...

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Detalles Bibliográficos
Autores principales: Fodor, Anthony A, Tickle, Timothy L, Richardson, Christine
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929139/
https://www.ncbi.nlm.nih.gov/pubmed/17472745
http://dx.doi.org/10.1186/gb-2007-8-5-r69

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929139/
https://www.ncbi.nlm.nih.gov/pubmed/17472745
http://dx.doi.org/10.1186/gb-2007-8-5-r69

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