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Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial

BACKGROUND: Medicine usage in Parkinson's disease patients is often imperfect, in particular irregular timing of medication. The effect of informing Parkinson's disease patients about the continuous dopaminergic hypothesis (to encourage regular medicine intake) on medication adherence and...

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Autores principales: Grosset, Katherine A, Grosset, Donald G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1931606/
https://www.ncbi.nlm.nih.gov/pubmed/17634109
http://dx.doi.org/10.1186/1471-2377-7-20
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author Grosset, Katherine A
Grosset, Donald G
author_facet Grosset, Katherine A
Grosset, Donald G
author_sort Grosset, Katherine A
collection PubMed
description BACKGROUND: Medicine usage in Parkinson's disease patients is often imperfect, in particular irregular timing of medication. The effect of informing Parkinson's disease patients about the continuous dopaminergic hypothesis (to encourage regular medicine intake) on medication adherence and motor control was tested. METHODS: Patients were randomised either to the active group (receiving the intervention) or control group (no extra information). Antiparkinson medicine usage was monitored for 3 months before and after the intervention using electronic pill bottles which record the date and time of opening (MEMS(®), Aardex, Switzerland) and data used to calculate the percentage of doses taken at correct time intervals. RESULTS: 43 patients (52%) were randomised to active counselling, and 40 (48%) were controls (standard management). The intervention effect (difference in timing adherence pre- to post-intervention between the 2 groups) was 13.4% (CI 5.1 to 21.7), p = 0.002. Parkinson motor scores did not change significantly (active group 0.1, CI -3.4 to 3.7) versus controls (4.5, CI 1.6 to 7.1), p = 0.06. CONCLUSION: Timing adherence, but not motor scores, improves by providing patients with extra information. Therapy timing is of potential importance in Parkinson's disease management. TRIAL REGISTRATION NUMBER: NCT00361205
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spelling pubmed-19316062007-07-25 Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial Grosset, Katherine A Grosset, Donald G BMC Neurol Research Article BACKGROUND: Medicine usage in Parkinson's disease patients is often imperfect, in particular irregular timing of medication. The effect of informing Parkinson's disease patients about the continuous dopaminergic hypothesis (to encourage regular medicine intake) on medication adherence and motor control was tested. METHODS: Patients were randomised either to the active group (receiving the intervention) or control group (no extra information). Antiparkinson medicine usage was monitored for 3 months before and after the intervention using electronic pill bottles which record the date and time of opening (MEMS(®), Aardex, Switzerland) and data used to calculate the percentage of doses taken at correct time intervals. RESULTS: 43 patients (52%) were randomised to active counselling, and 40 (48%) were controls (standard management). The intervention effect (difference in timing adherence pre- to post-intervention between the 2 groups) was 13.4% (CI 5.1 to 21.7), p = 0.002. Parkinson motor scores did not change significantly (active group 0.1, CI -3.4 to 3.7) versus controls (4.5, CI 1.6 to 7.1), p = 0.06. CONCLUSION: Timing adherence, but not motor scores, improves by providing patients with extra information. Therapy timing is of potential importance in Parkinson's disease management. TRIAL REGISTRATION NUMBER: NCT00361205 BioMed Central 2007-07-16 /pmc/articles/PMC1931606/ /pubmed/17634109 http://dx.doi.org/10.1186/1471-2377-7-20 Text en Copyright © 2007 Grosset and Grosset; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Grosset, Katherine A
Grosset, Donald G
Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial
title Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial
title_full Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial
title_fullStr Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial
title_full_unstemmed Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial
title_short Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial
title_sort effect of educational intervention on medication timing in parkinson's disease: a randomized controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1931606/
https://www.ncbi.nlm.nih.gov/pubmed/17634109
http://dx.doi.org/10.1186/1471-2377-7-20
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