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Nitroimidazole Action in Entamoeba histolytica: A Central Role for Thioredoxin Reductase
Metronidazole, a 5-nitroimidazole drug, has been the gold standard for several decades in the treatment of infections with microaerophilic protist parasites, including Entamoeba histolytica. For activation, the drug must be chemically reduced, but little is known about the targets of the active meta...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933457/ https://www.ncbi.nlm.nih.gov/pubmed/17676992 http://dx.doi.org/10.1371/journal.pbio.0050211 |