Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genome

We have analyzed a SIV deletion mutant that was compromised both in viral replication and RNA packaging. Serial passage of this variant in two different T-cell lines resulted in compensatory reversion and the generation of independent groups of point mutations within each cell line. Within each grou...

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Detalles Bibliográficos
Autores principales: Whitney, James B, Wainberg, Mark A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934378/
https://www.ncbi.nlm.nih.gov/pubmed/17608929
http://dx.doi.org/10.1186/1742-4690-4-44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934378/
https://www.ncbi.nlm.nih.gov/pubmed/17608929
http://dx.doi.org/10.1186/1742-4690-4-44

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