Conformational and thermodynamic changes of the repressor/DNA operator complex upon monomerization shed new light on regulation mechanisms of bacterial resistance against β-lactam antibiotics

In absence of β-lactam antibiotics, BlaI and MecI homodimeric repressors negatively control the expression of genes involved in β-lactam resistance in Bacillus licheniformis and in Staphylococcus aureus. Subsequently to β-lactam presence, BlaI/MecI is inactivated by a single-point proteolysis that s...

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Detalles Bibliográficos
Autores principales: Boudet, Julien, Duval, Valérie, Van Melckebeke, Hélène, Blackledge, Martin, Amoroso, Ana, Joris, Bernard, Simorre, Jean-Pierre
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1935004/
https://www.ncbi.nlm.nih.gov/pubmed/17576674
http://dx.doi.org/10.1093/nar/gkm448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1935004/
https://www.ncbi.nlm.nih.gov/pubmed/17576674
http://dx.doi.org/10.1093/nar/gkm448

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