Cytotoxic G-rich oligodeoxynucleotides: putative protein targets and required sequence motif

It has recently been shown that certain oligodeoxynucleotides (ODNs) designed as catalytic DNA molecules (DNAzymes) exhibit potent cytotoxicity independent of RNA-cleavage activity in a number of cell lines. These cytotoxic ODNs all featured a 5′ G-rich sequence and induced cell death by a TLR9-inde...

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Detalles Bibliográficos
Autores principales: Goodchild, Amber, King, Andrew, Gozar, Mary Margaret, Passioura, Toby, Tucker, Carly, Rivory, Laurent
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1935016/
https://www.ncbi.nlm.nih.gov/pubmed/17586818
http://dx.doi.org/10.1093/nar/gkm465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1935016/
https://www.ncbi.nlm.nih.gov/pubmed/17586818
http://dx.doi.org/10.1093/nar/gkm465

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