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Recombinant production of Streptococcus equisimilis streptokinase by Streptomyces lividans

BACKGROUND: Streptokinase (SK) is a potent plasminogen activator with widespread clinical use as a thrombolytic agent. It is naturally secreted by several strains of beta-haemolytic streptococci. The low yields obtained in SK production, lack of developed gene transfer methodology and the pathogenes...

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Detalles Bibliográficos
Autores principales: Pimienta, Elsa, Ayala, Julio C, Rodríguez, Caridad, Ramos, Astrid, Van Mellaert, Lieve, Vallín, Carlos, Anné, Jozef
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936427/
https://www.ncbi.nlm.nih.gov/pubmed/17610745
http://dx.doi.org/10.1186/1475-2859-6-20