Substitution as a Mechanism for Genetic Robustness: The Duplicated Deacetylases Hst1p and Sir2p in Saccharomyces cerevisiae

How duplicate genes provide genetic robustness remains an unresolved question. We have examined the duplicated histone deacetylases Sir2p and Hst1p in Saccharomyces cerevisiae and find that these paralogs with non-overlapping functions can provide genetic robustness against null mutations through a...

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Detalles Bibliográficos
Autores principales: Hickman, Meleah A, Rusche, Laura N
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1937012/
https://www.ncbi.nlm.nih.gov/pubmed/17676954
http://dx.doi.org/10.1371/journal.pgen.0030126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1937012/
https://www.ncbi.nlm.nih.gov/pubmed/17676954
http://dx.doi.org/10.1371/journal.pgen.0030126

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