Cargando…
STAT5 Is an Ambivalent Regulator of Neutrophil Homeostasis
BACKGROUND: Although STAT5 promotes survival of hematopoietic progenitors, STAT5(−/−) mice develop mild neutrophilia. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that in STAT5(−/−) mice, liver endothelial cells (LECs) autonomously secrete high amounts of G-CSF, allowing myeloid progenitors to over...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939728/ https://www.ncbi.nlm.nih.gov/pubmed/17710127 http://dx.doi.org/10.1371/journal.pone.0000727 |